a tool for identifying drug-targetable redox-active disulphides

Major urinary protein 1

Intramolecular

Cysteine 82 and cysteine 175

A redox-regulated disulphide may form within Major urinary protein 1 between cysteines 82 and 175 (64 and 157 respectively in this structure).

Details

Redox score ?

91

PDB code

Structure name

thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2- methoxy-3-isobutylpyrazine to the major urinary protein

Structure deposition date

2003-09-09

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

82

Residue number B

175

Peptide name

Major urinary protein 1

Ligandability

Cysteine 82 of Major urinary protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Major urinary protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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